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Epitalon

Name: Epitalon
Brand: Peptalon
SKU: PE-0071-01-10
Availability: InStock
Rating: 4.8 (127 reviews)

Epitalon is a synthetic tetrapeptide that stimulates telomerase activity, helping to preserve DNA integrity and slow the cellular aging process.

From 40,00 €

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Key Ingredients

Epitalone

Fights Signs of Aging

Repair DNA

Immune System Support

Fights Signs of Aging (01)

Balances circadian rhythm

Balance Hormones

Enhances Restful Sleep

Supports Longevity

Safe For Prolongued Use

Supports Healthy Aging

Safe and Natural

Not sure about the right dosage?

Use our Peptide Dosage Calculator for optimal application

Main Information

Epitalon (also known as Epithalon) is a synthetic peptide derived from Epithalamin, a natural pineal gland extract discovered by Russian researcher Prof. Vladimir Khavinson. This tetrapeptide (Ala-Glu-Asp-Gly) has shown strong evidence for telomerase activation, which may result in extended cellular lifespan, improved DNA repair, and delayed aging markers.

Epitalon also plays a crucial role in circadian rhythm control by enhancing melatonin secretion through its action on the pineal gland. Research has linked Epitalon with:

Improved sleep quality

Regulation of biological rhythms

Enhanced immune function

Slower onset of age-related disease

Increased stress resilience at the cellular level

Scientific Background

Epitalon (also known as Epithalamin or Ala-Glu-Asp-Gly) is a synthetic tetrapeptide that mimics a naturally occurring compound secreted by the pineal gland. It was originally developed by Russian scientist Prof. Vladimir Khavinson as part of anti-aging and geroprotection research conducted at the St. Petersburg Institute of Bioregulation and Gerontology.Epitalon gained scientific attention for its ability to regulate melatonin secretion, modulate gene expression, and influence telomerase activity — an enzyme responsible for maintaining the length of telomeres, which protect DNA during cell division. Shortened telomeres are considered one of the hallmarks of aging.

In a landmark animal study, Epitalon administration led to increased telomerase activity, lengthened telomeres, and extended lifespan in mice (Khavinson et al., 2003). Further research in aged monkeys and rats demonstrated improvements in immune function, circadian rhythm regulation, and stress resilience (Anisimov et al., 2001).One of Epitalon’s most cited benefits is its normalization of melatonin production, which often declines with age. Human studies in elderly subjects showed that Epitalon could restore youthful sleep-wake cycles and increase nighttime melatonin levels without causing dependence or hormonal suppression (Khavinson et al., 2002).While Epitalon remains a research compound in most countries, its low toxicity and favorable safety profile have made it a subject of ongoing clinical and anti-aging interest.

In summary, research suggests that Epitalon may support:

Telomere maintenance and genomic stability

Improved sleep quality via natural melatonin regulation

Immune system modulation and oxidative stress reduction

Potential lifespan extension and delayed onset of age-related decline

References

Khavinson V. et al. Epithalamin increases telomerase activity and telomere length in human somatic cells. Bull Exp Biol Med. 2003;135(4):430–432. [PMID: 14631492]
Anisimov VN et al. Effect of peptide Epitalon on biomarkers of aging, survival and spontaneous tumor incidence in rats. Biogerontology. 2001;2(2):89–99. [PMID: 11703967]
Khavinson V. et al. Pineal peptide preparations normalize melatonin synthesis in aging humans. Neuro Endocrinol Lett. 2002;23(Suppl 1):45–48. [PMID: 12496769]

Usage Instructions

General Instructions for Use

Epitalon is typically administered via subcutaneous injection, often in cycles.

Reconstitution:

Add 1–2 ml of bacteriostatic water to vial
Swirl gently to dissolve (do not shake)
Store reconstituted solution refrigerated (2–8 °C)
Use within 7–10 days of mixing

Dosage Information

Longevity / Anti-Aging Protocol:

Dose: 5–10 mg per day, split into 2 daily injections (morning + evening)
Cycle: 10–20 days per quarter (repeat 2–4× per year)
Ideal for long-term use in anti-aging strategies

Sleep & Circadian Rhythm Support:

Dose: 2.5–5 mg before bed
Duration: 10–15 days
May improve melatonin balance and sleep quality

Recovery / Regeneration Phase:

Dose: 5 mg daily for 10–20 days post-stress, illness, or travel
Can be stacked with DSIP, NAD+, or MOTS-c in longevity stacks

Important Warnings

For research or advanced longevity use only – not FDA-approved
Store unmixed vial refrigerated (2–8 °C)
Use reconstituted solution within 7–10 days
Do not freeze
Generally well tolerated; minor side effects may include transient fatigue, vivid dreams, or temporary headache
Avoid use with strong immunosuppressants or melatonin antagonists
Best used cyclically, not continuously.

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Knowledge that might interest you

What Is Epitalon? The Telomerase-Activating Anti-Aging Peptide

Can a Peptide Help Slow the Aging Clock? Aging is inevitable—but how we age is no longer just left to chance. Over the past few decades, researchers h...

In summary, research suggests that Epitalon may support:

Telomere maintenance and genomic stability

Improved sleep quality via natural melatonin regulation

Immune system modulation and oxidative stress reduction

Potential lifespan extension and delayed onset of age-related decline

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