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ARA 290

Name: ARA 290
Brand: Peptalon
SKU: PE-0277-01-50
Availability: InStock
Rating: 4.8 (127 reviews)

Supports nerve regeneration, reduces chronic pain, and promotes overall recovery in stress- and damage-affected tissues.

From 55,00 €

Format:

Anti inflammatory

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Main Information

ARA 290 is a novel therapeutic peptide derived from the structure of erythropoietin (EPO), engineered to provide anti-inflammatory and tissue-protective effects without stimulating red blood cell production. It acts on the innate repair receptor (IRR), modulating inflammation, protecting nerves, and promoting tissue regeneration. This makes ARA 290 especially beneficial for chronic pain management, metabolic regulation, and recovery in stress- or damage-related conditions.

Scientific Background

Unlike EPO, which primarily regulates erythropoiesis, ARA 290 was developed to selectively activate the tissue-protective domains of the erythropoietin receptor complex while avoiding hematopoietic effects. Its action centers on the innate repair receptor (IRR), a receptor formed by the heterodimer of EPOR and CD131.Through this pathway, ARA 290 reduces pro-inflammatory cytokine release, limits oxidative stress, and supports neuroprotection [1]. Clinical studies show improvements in neuropathic pain and small fiber neuropathy, particularly in diabetes-related cases [2]. Additionally, ARA 290 has demonstrated positive effects on insulin sensitivity and endothelial function [3], making it a promising agent in both pain medicine and metabolic health.

References

1.Brines M, Cerami A. The receptor that tames the innate immune response. Mol Med. 2012;18:486–496.
2.Brines M, et al. ARA 290, a non-erythropoietic peptide engineered from erythropoietin, improves neuropathic symptoms in patients with diabetes. Mol Med. 2014;20:658–666.
3.Dahan A, et al. ARA 290 improves metabolic control and endothelial function in patients with type 2 diabetes. Mol Med. 2013;19:94–102.

Usage Instructions

ARA 290 is an injectable peptide designed to modulate inflammation, protect nerves, and support tissue recovery. For detailed instructions please refer to the leaflet provided with your product package. Here are the most important instructions at a glance :

Administration route: Subcutaneous (preferred) or intramuscular
Needle size: 29–31G (subQ) or 25–27G (IM)
Preparation: Ready-to-inject solution or reconstituted lyophilized powder
Storage: Refrigerate at 2–8 °C; protect from light
Timing: Morning or post-training, depending on goal (pain vs. recovery)

Dosage Information

Neuropathic Pain / Nerve Regeneration

0.5 mL daily for 4–6 weeks
Evaluate clinical response; may transition to maintenance dosing

Metabolic Support (Diabetes / Insulin Sensitivity)

0.5–1 mL, 3× per week
Use as part of a supervised protocol for metabolic regulation

Recovery & Anti-Inflammatory Protocol

0.5–1 mL, 2–3× per week
Useful during high systemic inflammation, post-injury, or stress phases

Important Warnings

Do not exceed 1 mL daily unless supervised by a healthcare provider
Not recommended for individuals with active cancers (due to regenerative pathways)
Avoid during pregnancy or breastfeeding
Use with caution if you are on immunosuppressive or anti-inflammatory medication
Mild side effects may include local irritation, headache, or temporary fatigue
Always use sterile injection technique and rotate injection sites

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Administration route: Subcutaneous (preferred) or intramuscular
Needle size: 29–31G (subQ) or 25–27G (IM)
Preparation: Ready-to-inject solution or reconstituted lyophilized powder
Storage: Refrigerate at 2–8 °C; protect from light
Timing: Morning or post-training, depending on goal (pain vs. recovery)

Dosage Information

Neuropathic Pain / Nerve Regeneration

0.5 mL daily for 4–6 weeks
Evaluate clinical response; may transition to maintenance dosing

Metabolic Support (Diabetes / Insulin Sensitivity)

0.5–1 mL, 3× per week
Use as part of a supervised protocol for metabolic regulation

Recovery & Anti-Inflammatory Protocol

0.5–1 mL, 2–3× per week
Useful during high systemic inflammation, post-injury, or stress phases

Important Warnings

Do not exceed 1 mL daily unless supervised by a healthcare provider
Not recommended for individuals with active cancers (due to regenerative pathways)
Avoid during pregnancy or breastfeeding
Use with caution if you are on immunosuppressive or anti-inflammatory medication
Mild side effects may include local irritation, headache, or temporary fatigue
Always use sterile injection technique and rotate injection sites

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