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SS 31

Name: SS 31
Brand: Peptalon
SKU: PE-0289-01-10
Availability: InStock
Rating: 4.8 (127 reviews)

SS31 has shown potential to reduce oxidative stress, improve energy metabolism, and protect tissues from age- and stress-related damage.

From 55,00 €

Format:

Do not freeze

Do not shake

GMP certified

Protect from sun

Refrigerate

Not sure about the right dosage?

Use our Peptide Dosage Calculator for optimal application

Main Information

SS-31, also known as Elamipretide, is a mitochondria-targeting peptide engineered to bind selectively to cardiolipin in the inner mitochondrial membrane. By stabilizing mitochondrial structure and function, it enhances ATP production, reduces oxidative stress, and protects cells against damage. SS-31 is being studied for applications in energy metabolism, cardiovascular health, neuroprotection, and healthy aging.

Scientific Background

Mitochondria are often called the “power plants” of our cells because they produce the energy (ATP) we need to function. Over time, however, age, stress, and disease can damage their delicate membranes. This damage leads to less efficient energy production and more harmful by-products called reactive oxygen species (ROS), which accelerate cell stress and aging.

SS-31 is a small, specially designed peptide that can enter cells and go directly to the mitochondria. It binds to cardiolipin, a key component of the inner mitochondrial membrane, helping to stabilize and repair it. By doing so, SS-31 supports healthy mitochondrial shape and function, boosts energy output, and reduces the buildup of damaging ROS.

This peptide was originally developed through research into therapies for heart disease and muscle disorders, where mitochondrial damage is a major factor. Since then, preclinical and clinical studies have shown its potential benefits in conditions like heart failure, neurodegeneration, and age-related fatigue.

Today, SS-31 is considered a promising mitochondria-targeting tool for those interested in energy optimization, recovery, and longevity protocols.

References

Szeto HH. First-in-class cardiolipin-protective compound as a therapeutic agent to restore mitochondrial bioenergetics. Br J Pharmacol. 2014;171(8):2029–2050.
Birk AV, et al. The mitochondrial-targeted compound SS-31 re-energizes ischemic mitochondria. Pharm Res. 2013;30(8):2017–2024.
Daubert MA, et al. Elamipretide improves mitochondrial function in patients with heart failure with reduced ejection fraction. Circ Heart Fail. 2017;10(12):e004389.

Usage Instructions

You find the most important facts concerning usage below. For detailed guidance on preparation, administration, and dosage of your product, please refer to the product leaflet provided with your package or at the bottom of this page.

Administration route: Subcutaneous (preferred) or intravenous (research context)
Needle size: 29–31G (subQ) or standard IV equipment under clinical supervision
Preparation: Reconstitute lyophilized vial with bacteriostatic water; swirl gently
Storage: Lyophilized: –20 °C; reconstituted: refrigerate 2–8 °C, protect from light
Timing: Administer daily or before high physical/oxidative stress periods

Dosage Information

Energy & Recovery Support

2–5 mg subQ daily for 5–10 days
Enhances energy availability and reduces fatigue during stress

Cardiovascular / Longevity Protocol (Research Context)

3–10 mg subQ daily or every other day for 2–4 weeks

Designed to support cardiac and vascular mitochondrial health

Neuroprotection & Stress Resilience

2–5 mg daily, 5 days per week for 2–3 weeks

Often combined with NAD+ or metabolic cofactors for synergistic support

Important Warnings

Research use only; not FDA/EMA approved for therapy outside clinical trials
Do not exceed suggested doses without professional oversight
Not recommended during pregnancy or breastfeeding
Potential mild side effects: injection-site irritation, transient headache, flushing
Caution in individuals with renal impairment or severe metabolic disorders
Discontinue immediately if allergic reaction, dizziness, or unusual fatigue occurs
Always use sterile injection technique and rotate sites

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Administration route: Subcutaneous (preferred) or intravenous (research context)
Needle size: 29–31G (subQ) or standard IV equipment under clinical supervision
Preparation: Reconstitute lyophilized vial with bacteriostatic water; swirl gently
Storage: Lyophilized: –20 °C; reconstituted: refrigerate 2–8 °C, protect from light
Timing: Administer daily or before high physical/oxidative stress periods

Dosage Information

Energy & Recovery Support

2–5 mg subQ daily for 5–10 days
Enhances energy availability and reduces fatigue during stress

Cardiovascular / Longevity Protocol (Research Context)

3–10 mg subQ daily or every other day for 2–4 weeks

Designed to support cardiac and vascular mitochondrial health

Neuroprotection & Stress Resilience

2–5 mg daily, 5 days per week for 2–3 weeks

Often combined with NAD+ or metabolic cofactors for synergistic support

Important Warnings

Research use only; not FDA/EMA approved for therapy outside clinical trials
Do not exceed suggested doses without professional oversight
Not recommended during pregnancy or breastfeeding
Potential mild side effects: injection-site irritation, transient headache, flushing
Caution in individuals with renal impairment or severe metabolic disorders
Discontinue immediately if allergic reaction, dizziness, or unusual fatigue occurs
Always use sterile injection technique and rotate sites

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