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Peptides Line

DSIP 10

Name: DSIP 10
Brand: Peptalon
SKU: PE-0113-02-43
Availability: InStock
Rating: 4.8 (127 reviews)

DSIP has potential therapeutic benefits due to its ability to regulate the sleep-wake cycle and reduce stress. Some of the potential therapeutic benefits of DSIP include:

From $42.00

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Key Ingredients

Delta-sleep-inducing peptide

Boost Focus

Balance Hormones

Boosts Recovery

Enhances Memory

Safe For Prolongued Use

Product Information

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Main Information

Structurally, DSIP is a short peptide consisting of 9 amino acids. It has a characteristic sequence of amino acids that is important for its biological activity. The specific structure of DSIP allows it to bind to certain receptors in the brain and thus exert its effects.

The positive effects of DSIP on the sleep-wake cycle are mediated in various ways:

Sleep Regulation: Studies have shown DSIP to increase the duration of slow-wave sleep (delta sleep), which is a deep sleep stage important for body recovery and memory formation.

Stress Reduction: DSIP has also shown stress-reducing properties by decreasing the release of stress hormones like cortisol. This can help promote calmer and more restful sleep.

Pain Modulation: There is evidence that DSIP also plays a role in modulating pain sensations. By reducing pain, DSIP can indirectly contribute to better sleep, as pain often disrupts sleep.

Scientific Background

Delta Sleep-Inducing Peptide (DSIP) is a naturally occurring neuropeptide first isolated in the 1970s by Swiss scientists Schoenenberger and Monnier, who discovered it in the cerebral venous blood of rabbits during sleep. Initially recognized for its role in promoting deep sleep—particularly the delta wave phase—DSIP has since been found to exert a wide array of physiological effects, including stress modulation, hormonal regulation, and neuroprotection.

Discovery and Development

The peptide’s name reflects its original promise: inducing delta-sleep activity in EEG recordings. Since its discovery, DSIP has fascinated researchers due to its unusual stability and broad biological effects despite its small size (just 9 amino acids: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu). Unlike most peptides that are quickly broken down, DSIP resists enzymatic degradation, allowing it to function both centrally in the brain and peripherally throughout the body.Although the complete picture of its receptor interaction remains elusive, DSIP appears to modulate GABAergic, NMDA, and other neuroendocrine pathways, which helps explain its diverse functional profile.

DSIP’s effects are pleiotropic—meaning it influences multiple biological systems:

Sleep Regulation: Enhances slow-wave (delta) sleep phases and may reduce sleep latency.

Stress Reduction: Modulates ACTH and cortisol secretion, helping regulate the HPA axis during chronic stress.

Hormonal Balance: Influences luteinizing hormone (LH) and growth hormone (GH) levels.
Pain and Inflammation: Demonstrates mild analgesic and anti-inflammatory properties in some models.
Neuroprotection: Shows antioxidant effects and protects neurons from oxidative stress and ischemic damage.
Circadian Rhythm Stabilization: May help resynchronize disrupted sleep-wake cycles in shift workers or jet lag sufferers.

References

Sleep-Induction: Original studies by Monnier & Schoenenberger (1977) showed DSIP promoted delta-wave sleep when injected into animals (Helv Physiol Pharmacol Acta, 35(5): C47-C56).
Stress and HPA Axis: Graf et al. (1984) demonstrated DSIP reduces corticotropin-releasing hormone (CRH) activity under stress conditions (Neuroendocrinology, 38(5): 431–436).
Withdrawal Effects: Sudakov et al. (1999) explored its role in mitigating alcohol withdrawal in rats (Bull Exp Biol Med, 128(5): 1007–1010).
Neuroprotection: A 2005 paper by Kovalzon et al. reported antioxidant and anti-apoptotic activity of DSIP in neuronal cells exposed to oxidative stress (Neurosci Behav Physiol, 35(4): 387–390).

Usage Instructions

Recommended Use:

DSIP is typically used to support deep sleep quality and nervous system recovery
Administration: Subcutaneous injection (under the skin), ideally 30–60 minutes before bedtime.
Protocol: Use 100–200 mcg per night, for 5 to 14 consecutive nights as a reset protocol.
Best used in combination with good sleep hygiene (low light, reduced screen time, regular schedule).

Dosage Information

Standard Dose: 100–200 mcg per dose

Frequency: Once daily, preferably in the evening

Duration: Use for short cycles (5–14 days), then pause

Stacking Tip: DSIP may be combined with magnesium, theanine, or calming adaptogens for enhanced effect

Important Warnings

Warnings & Precautions

For research use only. Not approved for medical or therapeutic use by regulatory agencies.
Do not exceed recommended dosage.
Not for use during pregnancy or breastfeeding.
Avoid combining with sedatives or hypnotics unless supervised by a qualified professional.
Always use sterile technique for injections.
Store refrigerated (2–8 °C) and protect from light.

What Our Customers Say

“I struggled with chronic insomnia for years, trying everything from meditation to prescription medications. My work as an ER nurse with rotating shifts made it nearly impossible to maintain a regular sleep schedule. After starting DSIP therapy, I finally experience consistent, restorative sleep. I wake up feeling refreshed, even after switching between day and night shifts.”

Sarah Thompson

“As a professional MMA fighter, recovery is crucial. I started using DSIP peptides to help with post-training recovery and chronic shoulder pain. Not only has my sleep quality improved dramatically, but I've noticed faster muscle recovery and reduced inflammation after intense training sessions. It's become an essential part of my performance protocol.”

Marcus Chen

“Menopause-related sleep disturbances and anxiety were severely impacting my quality of life. Traditional sleep aids left me feeling groggy, but DSIP helps me maintain natural sleep patterns without morning drowsiness. The stress-reducing effects have been an unexpected bonus – I feel more balanced throughout the day.”

Jennifer Baker,

“Being a software developer with ADHD, I often struggled with racing thoughts at night and irregular sleep patterns. I started DSIP after my doctor recommended it as part of a comprehensive sleep hygiene plan. Now I can maintain a consistent sleep schedule, which has significantly improved my focus and productivity during the day."”

David Miller

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Discovery and Development

DSIP’s effects are pleiotropic—meaning it influences multiple biological systems:

Sleep Regulation: Enhances slow-wave (delta) sleep phases and may reduce sleep latency.

Stress Reduction: Modulates ACTH and cortisol secretion, helping regulate the HPA axis during chronic stress.

Hormonal Balance: Influences luteinizing hormone (LH) and growth hormone (GH) levels.
Pain and Inflammation: Demonstrates mild analgesic and anti-inflammatory properties in some models.
Neuroprotection: Shows antioxidant effects and protects neurons from oxidative stress and ischemic damage.
Circadian Rhythm Stabilization: May help resynchronize disrupted sleep-wake cycles in shift workers or jet lag sufferers.

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DSIP 10