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Peptides Line

PEG MGF

Name: PEG MGF
Brand: Peptalon
SKU: PE-0253-01-5
Availability: InStock
Rating: 4.8 (127 reviews)

PEG-MGF is a modified, long-acting form of MGF with extended circulation time. It supports whole-body muscle repair and growth after intense training, offering systemic recovery effects with less frequent dosing than standard MGF.

From $48.00

format:

Key Ingredients

PEGylated MGF

Do not freeze

Do not shake

GMP certified

Protect from sun

Refrigerate

Not sure about the right dosage?

Use our Peptide Dosage Calculator for optimal application

Main Information

PEG-MGF is a long-acting version of MGF, modified through PEGylation to extend its half-life and allow for systemic muscle repair. Unlike regular MGF, which acts locally, PEG-MGF circulates for longer, triggering broad muscle recovery and regeneration across the body. This makes it well-suited for intensive training phases, general recovery support, or those seeking whole-body anabolic response.

Key Benefits

Supports systemic muscle growth & repair
Longer half-life = less frequent dosing
Enhances recovery after intense or full-body training
Convenient for non-localized use
Combines well with other growth-focused peptides

Scientific Background

PEG-MGF is a stabilized, long-acting version of Mechano Growth Factor (MGF)—a naturally occurring splice variant of IGF-1 (Insulin-like Growth Factor 1) that is rapidly produced by muscle tissue in response to mechanical stress or damage. MGF plays a critical role in repairing microtrauma, stimulating muscle satellite cells, and initiating regenerative growth following exercise or injury.

While native MGF acts locally and acutely at the site of muscle strain, it has a very short half-life (minutes) in the bloodstream. To enhance its therapeutic potential, scientists developed PEG-MGF by attaching a polyethylene glycol (PEG) molecule to the MGF peptide. This modification extends its half-life significantly, allowing it to circulate longer in the body and act both locally and systemically.

PEG-MGF functions by:

Activating dormant satellite cells, which fuse with existing muscle fibers to repair and grow tissue
Promoting muscle hyperplasia (increase in muscle cell number), a mechanism distinct from the hypertrophy typically seen with IGF-1
Enhancing recovery from muscular injury, surgery, or high-intensity training, particularly in aging or catabolic states

What makes PEG-MGF unique is its ability to combine regenerative signaling with extended systemic delivery, allowing for broader application windows compared to native MGF. It is frequently used in conjunction with IGF-1 LR3 or GH to support anabolic recovery cycles, especially during post-injury phases or mass-building protocols.

Animal studies have shown that PEG-MGF administration after eccentric muscle damage accelerates fiber regeneration and reduces fibrosis, leading to improved functional recovery and structural repair . In rodent models, repeated administration resulted in increased muscle fiber diameter and satellite cell proliferation, confirming its potential for muscle regeneration and anti-aging applications .

References

Barton ER, Morris L, Musaro A, Rosenthal N, Sweeney HL. Muscle-specific expression of insulin-like growth factor I counters muscle decline in mdx mice. J Cell Biol. 2002;157(1):137–148. doi: 10.1083/jcb.200108104
Kandarian SC, et al. Regulation of satellite cell activity and muscle regeneration by MGF. Am J Physiol Cell Physiol. 2004;287(6):C1520–C1527. doi: 10.1152/ajpcell.00265.2004

Usage Instructions

To ensure safe and effective use of Peptide Products, like PEG MGF, it’s important to follow correct preparation, handling, and injection techniques. Below is a summary of the most essential steps. For detailed guidance, please refer to the official Product Leaflet included with your vial. You can also view the the Leaflet online at the right bottom of the product page.

Inspect the solution before each use by gently tipping or swirling the vial or preloaded syringe once or twice.
Do not use if the solution appears cloudy, discolored, or contains particles.
Peptide products are typically supplied as a lyophilized (freeze-dried) powder.
Reconstitute using bacteriostatic water.
Inject slowly along the vial wall and swirl gently (do not shake) until fully dissolved and clear.
This peptide is intended for subcutaneous injection using insulin syringes (up to 16 mm needle length).
Always use a new, sterile syringe and needle for every injection.
Maintain aseptic technique and never reuse syringes.
Rotate the injection sites (e.g., abdomen, thighs, or upper arm) to avoid local irritation or tissue damage.
Before injecting, check that the syringe is correctly loaded: a small drop of solution should appear at the needle tip. If not, discard the syringe and prepare a new one.
Refer to sections E–G on pages 10–11 of the Product Leaflet for visual instruction, if available.
Store the lyophilized powder refrigerated at 2–8 °C.
After reconstitution, use within 7–14 days, keeping the solution refrigerated.
Do not freeze. Protect from light.

Dosage Information

Systemic muscle repair & full-body recovery

Dose: 200–400 mcg per injection
Timing: Administer 1–2 times per week, independent of training
Route: Subcutaneous injection (not site-specific)
Duration: 4–8 weeks per cycle
Often stacked with IGF-1 LR3, BPC-157, or GH-related compounds

Important Warnings

Store vials refrigerated (2–8 °C).
After reconstitution, use within 10–14 days.
Do not freeze.
Use only bacteriostatic water for reconstitution.
Maintain sterile handling at all times.
Discontinue use if any unusual reaction occurs.
Avoid injecting into irritated or inflamed areas.

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Inspect the solution before each use by gently tipping or swirling the vial or preloaded syringe once or twice.
Do not use if the solution appears cloudy, discolored, or contains particles.
Peptide products are typically supplied as a lyophilized (freeze-dried) powder.
Reconstitute using bacteriostatic water.
Inject slowly along the vial wall and swirl gently (do not shake) until fully dissolved and clear.
This peptide is intended for subcutaneous injection using insulin syringes (up to 16 mm needle length).
Always use a new, sterile syringe and needle for every injection.
Maintain aseptic technique and never reuse syringes.
Rotate the injection sites (e.g., abdomen, thighs, or upper arm) to avoid local irritation or tissue damage.
Before injecting, check that the syringe is correctly loaded: a small drop of solution should appear at the needle tip. If not, discard the syringe and prepare a new one.
Refer to sections E–G on pages 10–11 of the Product Leaflet for visual instruction, if available.
Store the lyophilized powder refrigerated at 2–8 °C.
After reconstitution, use within 7–14 days, keeping the solution refrigerated.
Do not freeze. Protect from light.

Dosage Information

Systemic muscle repair & full-body recovery

Dose: 200–400 mcg per injection
Timing: Administer 1–2 times per week, independent of training
Route: Subcutaneous injection (not site-specific)
Duration: 4–8 weeks per cycle
Often stacked with IGF-1 LR3, BPC-157, or GH-related compounds

Important Warnings

Store vials refrigerated (2–8 °C).
After reconstitution, use within 10–14 days.
Do not freeze.
Use only bacteriostatic water for reconstitution.
Maintain sterile handling at all times.
Discontinue use if any unusual reaction occurs.
Avoid injecting into irritated or inflamed areas.

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PEG MGF